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The antibiotic resistome: gene flow in environments, animals and human beings
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics. Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks. However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene flow in nature is “from the natural environments” and “to the natural environments”; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene “circulation.”
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
《医学前沿(英文)》 2021年 第15卷 第5期 页码 693-703 doi: 10.1007/s11684-020-0777-6
关键词: S. typhi antibiotic resistance mechanism resistome identification methods
Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1466-7
• The α-diversities of resistome were lower in manure and compost than in soils.
关键词: Antibiotic resistance genes Resistome Bacterial taxonomy Transmission chain
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1189-1
关键词: Drinking water treatment Antibiotic resistance gene Biofiltration Chlorination
Culturomics and metagenomics: In understanding of environmental resistome
Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1121-8
State of the art of culturomics and metagenomics to study resistome was presented. The combination of culturomics and metagenomics approaches was proposed. The research directions of antibiotic resistance study has been suggested.
关键词: Culturomics Metagenomics Antibiotic resistance Resistome
红霉素发酵菌渣长期施用对土壤耐药基因的累积影响 Article
韩子铭, 冯皓迪, 栾晓, 沈云鹏, 任立人, 邓留杰, D.G. Joakim Larsson, Michael Gillings, 张昱, 杨敏
《工程(英文)》 2022年 第15卷 第8期 页码 78-88 doi: 10.1016/j.eng.2022.05.011
抗生素发酵生产过程产生的富含有机质的发酵菌渣具有资源化的潜力,但残留的高浓度抗生素限制了其资源化利用。本研究调研了一处工业规模的红霉素发酵菌渣(EFR)处理设施,并将一定条件下水热处理后的EFR作为有机肥,设置农业常规剂量和极端高剂量(3750~15 000 kg⋅hm−2),开展了连续三年的野外大田施用实验。水热处理有效地灭活了微生物,降解了DNA,红霉素的去除率达到约98%。菌渣有机肥的施用向土壤引入了持续三年的μg∙kg−1水平的亚抑制红霉素压力。土壤宏基因组测序发现,农业常规剂量施用对土壤耐药基因影响较弱,但极端高剂量施用对土壤耐药基因产生累积影响。具体而言,土壤耐药基因丰度和多样性没有受到单次(第一年)施用的影响,但在第二年和第三年期间逐渐发生变化,大环内酯类耐药基因被选择性富集。土壤细菌群落和可移动遗传元件的变化趋势与耐药基因相似,相关性分析和结构方程模型均表明三年期间红霉素、细菌群落、可移动遗传元件与耐药基因的关联性逐渐增强。被富集的大环内酯类耐药基因以RNA甲基化酶基因erm和外排泵基因mac为主;宏基因组组装与分箱结果表明,水平转移在erm基因的传播中发挥重要作用,mac基因的富集则主要受垂直传播的影响。本研究揭示了亚抑制水平红霉素长期暴露对土壤耐药基因产生累积影响的机制,菌渣中抗生素的高效去除和菌渣环境耐药性影响的长期评价对未来菌渣安全处置与资源化利用至关重要。
标题 作者 时间 类型 操作
Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review
Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu
期刊论文
Culturomics and metagenomics: In understanding of environmental resistome
Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza
期刊论文